Brock Purdy 9 hours ago 49ers QB Purdy discusses impact of losing CMC in loss to Bills 49ers quarterback Brock Purdy speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday night at Highmark Stadium. 49ers videos 2:23 Shanahan ready for CMC's return to backfield vs. Buccaneers 3:33 Maiocco: Short-handed 49ers score complete team win over Seahawks 1:40 Could Saleh rejoin 49ers this season after Jets fired him? 8:22 Shanahan discusses 49ers' prep for ‘explosive' Cardinals' attack 3:29 Maiocco: Mason ‘seized the moment' in 49ers' 32-19 win over Jets