The 49ers are at home for the second consecutive week as they welcome an NFC West opponent.
Kyler Murray and the Arizona Cardinals enter the contest with a 1-3 record after back-to-back home losses against the Detroit Lions and Washington Commanders, the latter being a 42-14 rout.
The 49ers are coming off a rout of their own, as they beat the New England Patriots 30-13 with Brock Purdy's heroics again standing out and the defensive line picking up steam.
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So, will the 49ers earn their first divisional win of the season? Here's how you can watch the Week 5 game from Levi's Stadium online or on TV:
When is the 49ers vs. Cardinals game?
The 49ers and Cardinals will meet Sunday, Oct. 6.
What time is the 49ers vs. Cardinals game?
San Francisco 49ers
Kickoff from Levi's Stadium is scheduled for 1:05 p.m. PT.
How to watch the 49ers vs. Cardinals Week 5 game live on TV
The 49ers vs. Cardinals game will air on FOX.
Local pregame coverage will begin at noon with "49ers Pregame Live" on NBC Sports Bay Area and streaming live on the NBC Sports app. "49ers Postgame Live" will begin immediately after the game, at approximately 4:30 p.m. PT, again on NBC Sports Bay Area and also streaming on the NBC Sports app.
How to live stream the 49ers vs. Cardinals Week 5 game
Live stream: FOX Sports, NFL+
Mobile app: FOX mobile app, NFL mobile app