What to Know
- Immediately after the Week 13 game ends, watch "49ers Postgame Live" on NBC Sports Bay Area or stream the show in the NBC Sports app for full reaction, analysis and interviews.
- The 49ers (5-6) enter Sunday's game having lost their last two contests. San Francisco's playoff odds are waning by the week, so a win in Buffalo would go a long way to keeping the team's postseason hopes alive.
- Buffalo (9-2) has won six consecutive games and currently is the AFC's No. 2 seed behind the Kansas City Chiefs (10-1).
- Running back Christian McCaffrey and linebacker Fred Warner are among Matt Maiocco's five 49ers to watch against the Bills.
- Quarterback Brock Purdy is playing against the Bills after missing the 49ers' last game against the Packers.
- Defensive end Nick Bosa, left tackle Trent Williams, left guard Aaron Banks, cornerback Deommodore Lenoir and defensive tackle Jordan Elliott were all ruled out for Sunday's game.
- Veteran cornerback Charvarius Ward returns to the lineup for the first time since Oct. 27 after his daughter, Amani Joy, tragically passed away.
Follow this live blog for the latest score updates, game highlights, news and analysis from Highmark Stadium in Buffalo: