What to know
- Programming note: Immediately after the 49ers play the Rams on Sunday at SoFi Stadium, watch "49ers Postgame Live" on NBC Sports Bay Area or stream the show in the NBC Sports app for full reaction, analysis and interviews.
- Both the 49ers (1-1) and Rams (0-2) are dealing with a multitude of injuries. San Francisco will be without stars Christian McCaffrey, Deebo Samuel and George Kittle, and edge rusher Nick Bosa and cornerback Charvarius Ward are questionable to play. Wide receivers Cooper Kupp and Puka Nacua are the most notable LA players who won't suit up.
- There is some good news for the 49ers, as safety Talanoa Hufanga made his 2024 season debut after recovering from a torn ACL. Linebacker Dee Winters also will play for the first time this season.
- With CMC, Samuel and Kittle all out, Matt Maiocco identified the five 49ers players to watch against the Rams.
Follow this live blog for the latest score updates, game highlights, news and analysis from SoFi Stadium in Inglewood: