San Francisco 49ers

Robert Griffin III outlined three reasons why the San Francisco 49ers have struggled this season.

In this episode of 49ers Overreactions, NBC Sports Bay Area’s Matt Maiocco examines whether San Francisco’s reliance on Christian McCaffrey led to his knee injury.

On “49ers Talk,” co-hosts Matt Maiocco and Jennifer Lee Chan debate if San Francisco currently is one of the NFL’s worst teams following consecutive blowout losses in Weeks 12 and 13.

49ers coach Kyle Shanahan spoke with the media on Monday following San Francisco’s 35-10 loss to the Buffalo Bills on Sunday night at Highmark Stadium about the team’s recent misfortunes on and off the field.

Sondra Williams, the wife of San Francisco 49ers star left tackle Trent Williams, announced the death of their stillborn son, Trenton O’Brien Williams Jr.

49ers fullback Kyle Juszczyk speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday night at Highmark Stadium.

Bills superstar Josh Allen became the first QB in NFL history to throw, catch and rush for a touchdown in the same game in Buffalo’s 35-10 rout of the San Francisco 49ers Sunday night at snowy Highmark Stadium.

49ers quarterback Brock Purdy speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday night at Highmark Stadium.

49ers tight end George Kittle speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday night at Highmark Stadium.

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners and losers.

Sunday night’s San Francisco 49ers-Buffalo Bills game in Orchard Park, New York will be a cold and snow-filled affair.

San Francisco 49ers rookie safety Malik Mustapha sits down with NBC Sports Bay Area’s Jennifer Lee Chan to talk about achieving his NFL dream and playing for the team he grew up rooting for.

49ers quarterback Brock Purdy speaks with reporters ahead of San Francisco’s Week 13 matchup against the Buffalo Bills on Sunday night.

San Francisco 49ers linebacker Fred Warner revealed he has been playing through a fractured ankle since Week 4 of the 2024 NFL season.

John Lynch joins Matt Maiocco on NBC Sports Bay Area’s “49ers Game Plan” to discuss Christian McCaffrey’s struggles since his return from Achilles tendinitis.

Nick Bosa speaks with reporters ahead of the San Francisco 49ers’ Week 13 matchup against the Buffalo Bills on Sunday at Highmark Stadium.

Christian McCaffrey speaks with reporters ahead of the San Francisco 49ers’ Week 13 matchup against the Buffalo Bills on Sunday at Highmark Stadium.

Deebo Samuel speaks with reporters ahead of the San Francisco 49ers’ Week 13 matchup against the Buffalo Bills on Sunday at Highmark Stadium.

Defensive coordinator Nick Sorensen speaks with reporters ahead of the San Francisco 49ers’ Week 13 matchup against the Buffalo Bills on Sunday at Highmark Stadium.

Fred Warner admits to playing through a fractured ankle ahead of the San Francisco 49ers’ Week 13 matchup against the Buffalo Bills on Sunday at Highmark Stadium.